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- W2364310984 abstract "Objective: To study the preventing effect of high nutrition of protein on iodide goiter.Methods: A total of 140 male Kunming mice were equally and randomly divided into 4 groups:high iodide (group H),casein 1 (group C 1),casein 2 (group C 2) and control (group N).The mice in group H,C 1 and C 2 were fed with water containing iodine 2500 μg/L,while those in group N were fed with running water containing iodine 7.5 μg/L.Group H and N were provided with common mouse diet form Animal Center of Henan Medical University,and group C 1 and C 2 fed respectively with the diet of group H added to 25% weight casein and 50% weight casein.After 150 days,all mice were killed and studied for thyroid weight,thyroid content by Riesco’s method,thyroid histology,thyroid peroxidase activity by guaiacol assay,and serum concentration of thyroid hormones and thyroid stimulating hormone by radioimmunoassay.Results: The mice in group H had more weighty thyroid,higher iodine content,higher serum FT 4 concentration,and lower thyroid peroxidase activity than those in group N,group C 1 and C 2.Thyroid histology in group H showed typical colloid goiter.Conclusion: Excessive iodine had some damages to thyroid epithelial cells.Diet with high casein can reduce the formation of excessive thyroid colloid in the follicular lumens,and effectively inhibit iodide goiter in mice.The mechanism may be that casein prevents excessive iodine from entering the thyroid." @default.
- W2364310984 created "2016-06-24" @default.
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- W2364310984 date "2000-01-01" @default.
- W2364310984 modified "2023-09-25" @default.
- W2364310984 title "The experimental study on high nutrition of protein in preventing excessive iodide induced goiter in mice" @default.
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