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- W2364321805 abstract "Objective To examine the effect of Arg - Gly - Asp- Ser (RGDS) peptides on serum collagen type Ⅲ of the hepatic fibrosis rat model. Methods 25 SD male rats were divided into 5 groups with 5 each. The normal control group only feeded without any drug. The other 20 rats were all injected subcutaneously with 40 % carbon tetrachloride (CCl4) olive oil by injection for 6 weeks to induce hepatic fibrosis. Thereafter, they continued to receive CCl4 injection and at the same time they were separately in geted with distilled water, arg-gly-glu-asp (RGES), RGDS, interferon(IFN) intraabdomial by every 3 days for 4 weeks. At last, rat sera were collected and stored in - 20℃ for determining collagen type Ⅲ and their hepatic tissues were examined with HE and VG stain to study the pathological changes. Results The levels of collagen type Ⅲ of group IFN and RGDS group(58.73 ± 8.18ng/ml and 64.35 ± 13.73ng/ml)were lower than those of live cirrhosis model control group and RGES group (126.02 ± 33.92ng/ml and 119. 61 ± 33.92ng/ml). Conclusion RGDS peptide can reduce serum collagen type Ⅲ of CCl4 in the induced hepatic fibrosis rat. RGES has no such biologic effect. RGD is one important structure." @default.
- W2364321805 created "2016-06-24" @default.
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- W2364321805 date "2001-01-01" @default.
- W2364321805 modified "2023-09-24" @default.
- W2364321805 title "Influence of Arg-Gly-Asp-Ser Peptides on Serum Collagen Type III of the Hepatic Fibrosis Rat Model" @default.
- W2364321805 hasPublicationYear "2001" @default.
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