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- W2364331946 abstract "It was well known that sexual difference exists in prognosis of trauma. Studies had revealed that there was a significantly higher incidence of life-threatening complications and mortality in traumatized males than in females. However, clinical studies had showed controversial results on the role of gender in outcomes of severe traumatic patients. Laboratory studies of trauma had confirmed that immune response was markedly depressed in males but was normalized in castrated males. Moreover, administration of testosterone receptor antagonist following trauma-hemorrhage could also improve immune, hepatic and cardiovascular functions. Several studies were conducted to explore the effect of sex hormones on immune response and organ functions following trauma. These results had showed that estrogen played an important role in mediating immunoprotective effects. In contrast, androgen was immunosuppressive. In this review, we discussed the effect of androgen on immune response, hepatic and cardiovascular functions in an experimental model of trauma-hemorrhage, and further analyzed the potential mechanism which responsible for gender dimorphism in outcomes of trauma patients. The results gained from the experimental studies would be helpful in designing innovative therapeutic approaches for the treatment of trauma patients." @default.
- W2364331946 created "2016-06-24" @default.
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- W2364331946 date "2014-01-01" @default.
- W2364331946 modified "2023-09-26" @default.
- W2364331946 title "Effect of androgen on immune response, hepatic and cardiovascular functions after severely traumatic injury" @default.
- W2364331946 hasPublicationYear "2014" @default.
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