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- W2364338112 abstract "Objective To analyze imaging manifestation of hepatocellular carcinoma treated by TACE combined with sorafenib,assess the curative effect of combined therapy and find out the possible imaging evidence of sorafenib for HCC.Methods From August 2008 to October 2010,30 cases(mean age,56 years;range,30~68 years) of HCC were treated by TACE combined with sorafenib.Follow-up was performed by CT/MR from 6 to 20 months,mean 9 months.Follow-up images were analyzed.Results Four types of CT imaging were found according to the distribution of lipiodol deposition in the lesion.Type I—the lesion displayed complete or partial low density without lipiodol deposition.TypeⅡ—the lesion displayed peripheral low density with central lipiodol deposition.Type III—the lesion displayed compact lipiodol deposition.Type IV—low density areas intermingled with lipiodol deposition areas in the lesion.Type I(n=5),TypeⅡ(n=3),Type III(n=6),and Type IV(n=15) were found in 29 cases.One patient stopped taking sorafenib after one week due to severe abdominal pain.The patients were divided into viable group and inviable group based on the dynamic contrast enhanced CT or MR imaging.Three patients had viable tumor and 2 patients had inviable tumor in Type I.The low density areas in Type I was inviable.Two patients had viable tumor and 1 patient had inviable tumor in TypeⅡ.Two patients had viable tumor and 4 patients had inviable tumor in Type III.All patients in Type IV had viable tumor.The low density areas in Type I were formed in the second to eighth follow-up month,mean 5.3 months.At the fifth follow up month,CR(n=3),PR(n=6),SD(n=11) and PD(n=9) were found in 29 cases on the basis of revised RECIST.The DCR was 68.97%.Conclusion CT and MR images can reflect curative effect of hepatocellular carcinoma treated by TACE combined with sorafenib.The low density area which is completely necrotic without lipiodol deposition in Type I may be caused by sorafenib." @default.
- W2364338112 created "2016-06-24" @default.
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- W2364338112 date "2012-01-01" @default.
- W2364338112 modified "2023-09-24" @default.
- W2364338112 title "Imaging analysis of hepatocellular carcinoma treated by TACE combined with sorafenib" @default.
- W2364338112 hasPublicationYear "2012" @default.
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