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- W2364338406 abstract "Objective To detect the changes of serum 8-iso-prostaglandin F2a(8-iso-PGF2a) and high sensitive C-reactive protein(hs-CRP) in acute myocardial infarction(AMI),and explore the the relationship between oxidative stress,inflammatory reaction and severity of coronary artery disease.Methods The serum hs-CRP and 8-iso-PGF2a concentrations of 50 patients and control subjects were measured by enzyme-linked immunosorbent assay(ELISA) and immunotransmission turbidimetry respectively.Meanwhile,coronary angiography was carried out simultaneously and the Gensini score were employed to evaluate degree of coronary artery disease,and the results were statistically analyzed.Results Compared with the normal control group,the serum hs-CRP and 8-iso-PGF2a concentrations of in patient group were significantly higher(P0.05),and were positively related with the Gensini score.The serum hs-CRP concentration also showed good positive relationship(r=0.9034,P0.05) with 8-iso-PGF2a.Conclusion The interaction between oxidative stress and inflammation lead to the emergence and development of AMI,and then the combined determination of the serum hs-CRP and 8-iso-PGF2a concentrations can better evaluate oxidative stress and inflammation states in AMI patients and guide antioxidation and anti-inflammatory treatment." @default.
- W2364338406 created "2016-06-24" @default.
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- W2364338406 date "2011-01-01" @default.
- W2364338406 modified "2023-09-27" @default.
- W2364338406 title "Relationship and Cinical Significance of Inflammation and Oxidative Stress in Acute Myocardial Infarction" @default.
- W2364338406 hasPublicationYear "2011" @default.
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