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- W2364339761 abstract "Objective:To elucidate the changes of distribution of endothelin 1(ET 1) in the traumatized spinal cord of the rat.Method:Sprague Dawleys rats (n=30) were randomly divided into six groups. A spinal cord injury model of the rat was induced by modified Allen's weight drop method (50g·cm). The changes of distribution of ET 1 in the injured spinal cord and adjacent sections were immunolocalized. The optical density of ET 1 of neurons in the adjacent sections of the injured site were measured by image pattern analysis.Result:Immunostaining for ET 1 almost distributed the whole grey matter of normal spinal cord of the rats,including neurons,glial cells,endothelial cells and interstitium. Prominent neuronal staining was noted. The distribution of ET 1 in injured spinal cord was similar to the normal spinal cord, but deeper staining was noted in injured spinal cord. There was a prominent increase in immunostaining in neurons and interstitium in injured spinal cord. The deepest staining consisted in the grey matter of 4h group after spinal cord injury. There was a significant incraese in immunostaining of ET 1 in neurons in traumatized spinal cord.Conclusion:The expression of ET 1 upregulates in injured spinal cord. Neuron may be a main contributor to the increase of ET 1 in injured spinal cord. Author′s address Department of Orthopedics, 1st Teaching Hospital of Sun Yat sen University of Medical Sciences,Guangzhou,Guangdong,510080" @default.
- W2364339761 created "2016-06-24" @default.
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- W2364339761 date "2000-01-01" @default.
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- W2364339761 title "Immunolocalization of endothelin 1 in spinal cord traumatized rats" @default.
- W2364339761 hasPublicationYear "2000" @default.
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