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- W2364341972 abstract "Objective:To observe the antioxidant effects of PNS on DN rat model and high glucose cultured cell.Methods:Unilateral nephrectomy and intraperitoneal injection of STZ(55mg/kg) was used to build diabetic rats that were divided into normal group,model group,IRB group,PNS group.Rat body weight,24-hour urine protein was test at 12 weeks,measured kidney weight body weight ratio,levels of serum TG,BUN,Scr,NO,MDA and SOD concentration;kidney HE,mallory,masson,methenamine silver staining;immunohistochemistry detection of renal TGF-β1 and Caspase-3 protein;RT-PCR detection of renal TGF-β1 and podocyte Caspase-3 mRNA.Results:Compared with model group,the kidney weight/body weight ratio of PNS group were significantly decreased(P0.05);the urine protein of PNS group was significantly decreased(P0.05) at the end of the 4,8,12week(P0.05).PNS also decrease the biochemical parameters such as BUN,Scr and TG.PNS groups SOD,NO were significantly increased(P0.05).TGF-β1 mRNA levels was significantly lower(P0.05) compared with model group,Caspase-3 gene level were significantly reduced(P0.05).Conclusion:Regulating renal TGF-β1,Caspase-3 gene expression may be one of the mechanisms of PNS therapeutic effect of DN." @default.
- W2364341972 created "2016-06-24" @default.
- W2364341972 creator A5091907911 @default.
- W2364341972 date "2011-01-01" @default.
- W2364341972 modified "2023-09-22" @default.
- W2364341972 title "Study on antioxidant effects and inhibition of podocyte apoptosis of PNS on DN rat" @default.
- W2364341972 hasPublicationYear "2011" @default.
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