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- W2364342443 abstract "Objective To demonstrate the feasibility of using amide proton transfer(APT)MR imaging to detect Parkinson's disease(PD)patients at 3 Tesla. Methods 27 PD patients(17 men and 10 women; age range, 54-77 years)and 22 age-matched normal controls(13 men and 9 women; age range, 55-73 years)underwent APT MR imaging. The magnetic resonance ratio asymmetry(MTRasym)values at 3.5 ppm of bilateral substantia nigra, red nucleus, globus pallidus, putamen and caudate were measured on APT images. MTRasym(3.5 ppm)values of cerebral structures between PD patients and control subjects were compared with independentsamples t test. Results The MTRasym(3.5 ppm)value of the substantia nigra was significantly lower in PD patients than in normal controls(1.0% ± 0.2 % vs. 1.3 % ± 0.2 %, P = 0.005). In contrast, the MTRasym(3.5 ppm)values of the globus pallidus, putamen, and caudate were significantly higher in PD patients than in normal control(s0.9 % ± 0.1 % vs. 0.5 % ± 0.2 %, P 0.001; 1.0 % ± 0.1 % vs. 0.8 % ± 0.2 %, P = 0.003; 1.1 % ± 0.1 % vs. 0.7 % ± 0.2 %, P 0.001, respectively). Conclusions APT may be a useful tool to evaluate cerebral abnormal metabolite of PD." @default.
- W2364342443 created "2016-06-24" @default.
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- W2364342443 date "2014-01-01" @default.
- W2364342443 modified "2023-09-27" @default.
- W2364342443 title "Feasibility of detecting parkinson's disease using amide proton transfer MR imaging" @default.
- W2364342443 hasPublicationYear "2014" @default.
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