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- W2364346209 abstract "Objective To investigate apoptotic effect of 2,5- Hexanedione( 2,5- HD) on bone marrow mesenchymal stem cells( BMSCs) of rats and its mechanism. Methods Thecellswere isolated from Bone marrows of rats and cultured.The morphology ofcells were observed,their surface markers were determined by flow cytomerty. Moreover,the cells could be induced tofat cells andosteoblasts. These cells were confirmed to be BMSCs. In this study,the fifth generation of rat BMSCs was exposed to 0,10,20 and 40 mmol /L 2,5- HD for 24 h and the cells viability was measured by MTT assay.Themorphological changes of BMSCs were observed using HE staining and The apoptotic morphologic changes of BMSCs were observed by Hoechst 33342 staining. The protein expression of Bcl- 2 and Baxwasdetermined by Western blot. Results Our results showed thatexposure to 2,5- HD decreased survival of BMSCs and induced apoptosis. Moreover,2,5-HD significantly increasedBaxexpression( P 0. 05) and significantly decreased Bcl- 2 expression( P 0. 05). Conclusion These results suggest that 2,5- HD- induced apoptosis of BMSCs may be associated withdisturbanceinBax /Bcl- 2 protein expression." @default.
- W2364346209 created "2016-06-24" @default.
- W2364346209 creator A5014600278 @default.
- W2364346209 date "2014-01-01" @default.
- W2364346209 modified "2023-09-24" @default.
- W2364346209 title "2,5-Hexanedione induces apoptosis inthemesenchymal stem cells from rat bone marrow" @default.
- W2364346209 hasPublicationYear "2014" @default.
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