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- W2364347011 abstract "Objective:To investigate the relationship between the gene polymorphism of tumor necrosis factor-α,human β-defensin-1 and the development of chronic obstructive pulmonary disease as well as to research the interactive effects between two genes.Methods:We use a case-control study to compare the frequent distribution of tumor necrosis factor-α,human β-defensin-1 genetypes with a polymerase chain reaction-fragment polymorphism(PCR-RFLP) method and to analyze the relationship between two genes.Results:The heterogenesis gene frequency of tumor necrosis factor-α in COPD group and control group were 16.41% and 8.04%,which difference was significant(P=0.006);The heterogenesis gene frequency of human β-defensin-1 was 15.23% in COPD group and 6.70% in control group with significant difference(P=0.003);Except human β-defensin-1 SNP,the relative risk of tumor necrosis factor-α SNP was 1.786.Except tumor necrosis factor-α SNP,the relative risk of human β-defensin-1 SNP was 7.082.The relative risk of tumor necrosis factor-αSNP and human β-defensin-1 SNP was 7.836.Conclusion:Polymorphism of tumor necrosis factor-α、human β-defensin-1 have relationship with the development of COPD,there is no interaction between tumor necrosis factor-α SNP and human β-defensin-1 SNP." @default.
- W2364347011 created "2016-06-24" @default.
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- W2364347011 date "2008-01-01" @default.
- W2364347011 modified "2023-09-22" @default.
- W2364347011 title "The Relationship between Genetic Polymorphism of Tumor Necrosis Factor-α,Human β-defensin-1 and the Development of Chronic Obstructive Pulmonary Disease" @default.
- W2364347011 hasPublicationYear "2008" @default.
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