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- W2364349568 abstract "AIM: To investigate the effect of fentanyl pretreatment on myocardial hypoxic-ischemic injury in rabbits with acute hemorrhagic shock. METHODS: Sixteen healthy white rabbits were randomly divided into 2 groups (n=8): control group (C group) and fentanyl pretreatment group (F group). Acute hemorrhagic animal models were established according to the Wigger's method. 15 min before bloodletting, the same volume of saline and fentanyl were given to group C and group F respectively. Keep the state of hemorrhagic shock for 90 min and take arterial blood before bloodletting (T_0), 60 min after bloodletting (T_4) and 90 min after bloodletting (T_6) for determination of serum cardiac Troponin I (cTnI) with chemiluminescence method. Heart functional parameters were recorded before bloodletting (T_0) and 15 (T_1), 30 (T_2), 45 (T_3), 60 (T_4), 75 (T_5) and 90 (T_6) min after bloodletting. Morphological change of the heart was observed by electron microscopy. RESULTS: The serum concentrations of cTnI increased significantly in the 2 groups at T_2 and T_3 as compared with T_1 (P0.01). cTnI values at T_2 and T_3 in group F were lower than those in group C (P0.01). Myocar- dial injury in group F was less severe than that in group C. CONCLUSION: Fentanyl pretreatment can reduce myocardial injury induced by acute hemorrhagic shock in rabbits." @default.
- W2364349568 created "2016-06-24" @default.
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- W2364349568 date "2007-01-01" @default.
- W2364349568 modified "2023-09-28" @default.
- W2364349568 title "Effect of fentanyl pretreatment on myocardial injury induced by acute hemorrhagic shock in rabbits" @default.
- W2364349568 hasPublicationYear "2007" @default.
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