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- W2364349724 abstract "Objective To investigate the relationship between neurogenic bowel dysfunction(NBD) and substance P in rats suffering from spinal cord injury(SCI). Methods 60 male Sprague-Dawley rats, weighted(220±40) g, were randomly divided into three groups: sham group(n=20), normal group(n=20) and model group(n=20) and then were subdivided into subgroups of 24 h, 1 week, 3 weeks, and 5weeks respectively after SCI. SCI model was established at thoracic 10 segment of rat with NYU impactor device. The colon tissue of the rats was resected and stored. Substance P in serum and tissue was measured by ELISA. The tissue was examined by real-time RT-PCR and Western blotting to analyze the expression of substance P. Results The colon intestinal transmission function decreased and delineated at minimum value at 3 weeks in the model group. There was statistical significance with respect to the content of substance P in serum and tissue between the sham group and model group at 3 weeks. The expression of substance P in the sham group was(3.12±0.51) times of the model group(P0.05). Conclusion Substance P may take part in NBD after SCI in rats." @default.
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- W2364349724 date "2014-01-01" @default.
- W2364349724 modified "2023-09-24" @default.
- W2364349724 title "Substance P in Neurogenic Bowel Dysfunction after Spinal Cord Injury in Rats" @default.
- W2364349724 hasPublicationYear "2014" @default.
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