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- W2364351610 abstract "Objective To investigate total glucosides of paeong(TGP) on insulin sensitivity and blood lipid in insulin resistant rats induced by high fat diet and its possible mechanism.Methods The rats were divided into normal group and test groups.The rats in test groups were fed with high fat diet for 8 weeks to induce the insulin resistant model.After the model was esthblished,the rats were divided into four groups randomly,the model group,the metformin group,the high-dose TGP group and the low-dose TGP group.All the rats were checked their levels of insulin,blood sugar,blood fat and counted the value of insulin sensitivity.Results Compared with the model group,the levels of insulin and IRI in metformin and high-dose TGP groups were reduced obviously (P0.01),and the ISI were increased obviously(P0.01).All the three drug-used groups could reduce the levels of TC,FFA,TG and LDL-C(P0.05 or P0.01),and increase the concentration of HDL-C(P0.05).Metformin did not affect FBG(P0.05),but reduced OGTT-2hBG(P0.05).Both high-dose TGP and low-dose TGP could affect FBG and OGTT-2hBG,but the difference were not significant(P0.05).Conclusion TGP could enhance insulin sensitivity hyperlipemic and insulin resistant rats' in induced by high fat diet,and reduce the levels of TC and TG,which maybe the most possible effective mechanism of improving insulin sensitivity by TGP." @default.
- W2364351610 created "2016-06-24" @default.
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- W2364351610 date "2008-01-01" @default.
- W2364351610 modified "2023-09-25" @default.
- W2364351610 title "Effects of Total Glucosides of Paeong on Insulin Sensitivity and Blood Lipid in Insulin Resistant Rats Induced by High Fat Diet" @default.
- W2364351610 hasPublicationYear "2008" @default.
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