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- W2364355250 abstract "Aim: To establish a rat digestive system injury model induced by carbamazepine(CBZ). Methods: A total of 72 rats were allocated into 2 groups. Normal control group(n=12) was only given distilled water by gavage and the model group(n=60) was given CBZ from a dose of 600 mg/kg and increased by 200 mg/kg every 5 d till increased to 1 200 mg/kg and maintained the dose till the end of administration.On the 30th d, 60th d, 90th d, 120th d, and 150th d, 12 rats in model group were executed and the hepatic function was assessed and the tissue from the liver, stomach, and small intestines was observed under light microscope and electron transmission microscope. Results: Normal control group was in good condition with normal histological structure; model group was in bad condition with diffuse edema of hepato- cytes, focal necrosis, and inflammatory cell infiltration in liver, gastric mucosa astropy,edema, inflammatory cell infiltration and superficial gastric ulcer as well as endoplasmic reticulum and mitochondrion swelling in hepatocytes and enlarged fat droplet; the serum levels of AST, ALT, and ALP increased and ALB decreased compared with normal control group( P0.05).Conclusion: The rat digestive system injury model induced by CBZ is successfully established." @default.
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- W2364355250 date "2005-01-01" @default.
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- W2364355250 title "Establishment of rat digestive system injury model induced by carbamazepine" @default.
- W2364355250 hasPublicationYear "2005" @default.
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