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- W2364359610 abstract "Objective To prolong the action times and reduce the administration times of Pyrolin.Then to synthesis ester derivatives of Pyrolin and screen the activity molecular with pharmacological experiment.Methods Five Pyrolin-acyl derivatives were prepared from Pyrolin,through the different methods of using before medicine principle to protect the two phenolic hydroxyl acylation of Pyrolin.Then the pharmacological function of five Pyrolin-acyl derivatives were investigated by death experiment of rats induced by staphylococcus aureus and escherichia coli.Results The structures of the target compounds were identified by IR,1H-NMR,13C-NMR and ESI-Ms,which were diacetyl-Pyrolin,dipropionyl-Pyrolin,dibenzoyl-Pyrolin,dinicotinate-Pyrolin,diacetyl-salicylic-Pyrolin.The antibacerial experiments in vivo showed the target compounds signicantly increased the survival rates of rats which were infected with escherichia coli and staphylococcus aureus(P0.01).The antibacterial effect of the target compounds were better than Pyrolin.Conclusion Five synthesized target compounds have good antibacterial activities in vivo,and they are valuable to further study." @default.
- W2364359610 created "2016-06-24" @default.
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- W2364359610 date "2012-01-01" @default.
- W2364359610 modified "2023-09-23" @default.
- W2364359610 title "Study on synthesis of Pyrolin ester derivatives and antibacterial activity" @default.
- W2364359610 hasPublicationYear "2012" @default.
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