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- W2364361288 abstract "Objective To explore the expression of vascular endothelial growth factor (VEGF) and its receptors FLT-1 and KDR in adult acute leukemia (AL). Methods mRNA expression of VEGF and its receptors in bone marrow mononuclear cells (BM MNCs) were determined by semi-quantitative RT-PCR. Results (1)The expression rate of VEGF mRNA in untreated AL patients had no significant difference compared with that in bone marrow remission (BMR) patients and in normal controls (P0.05). Relative expression level (VEGF/β-actin) in BM MNCs of untreatcd AL group was markedly higher than that of BMR group and normal control group (both,P0.01), but there was no significant difference between two later groups (P0.05). VEGF/β-actin level in untreated AML patients was significantly higher than that of untreated ALL patients (P0.05). (2)The positive expressions rate of FLT-1 and KDR mRNA in untreated AL patients was higher than that of BMR patients and normal controls (both,P0.05), while no significance was showed between two later groups (P0.05). The expression of BM MNCs KDR mRNA was significantly higher in AML patients than that in ALL patients (P0.05). Evaluating the relative quantity of FLT-1/β-actin、KDR/β-actin in corresponding groups, there were the similar results. (3)There was a positive correlation between the expression levels of VEGF, FLT-1 and KDR mRNA (both,P0.05). Conclusions VEGF and its receptors FLT-1 and KDR mRNA are overexpressed in BM MNCs of AL patients. The expression levels of VEGF and KDR mRNA in BM MNCs of AML patients are higher than those of ALL patients. Semi-quantitative RT-PCR can be supposed to be a better method to evaluate the VEGF mRNA expression." @default.
- W2364361288 created "2016-06-24" @default.
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- W2364361288 date "2004-01-01" @default.
- W2364361288 modified "2023-09-24" @default.
- W2364361288 title "Expression of vascular endothelial growth factor and its receptors FLT-1 and KDR in adult acute leukemia" @default.
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