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- W2364361502 abstract "Objective To study the pathological changes and imageological findings of preearly femoral head osteonecrosis in rabbits,in order to explore the diagnostic method.Materials and Methods Thirty New Zealand white adult rabbits were randomly divided into contral group(n=10) and experimental group(n=20).The rabbits were injected intramuscularly with 20mg/kg of methylprednisolone acetate for 3 days or saline in experimental group and contral group respectively.X-ray,CT,MRI and pathology were performed on femoral heads of two groups animals at the time of 2,3,4,5,6,7,8 weeks.Results The imageological examination demonstrated that plan-film and CT had no significant findings.However,MR imaging with STIR sequences showed high spot signal during 3 to 8 weeks.Histopathological findings revealed that the fat cells of the marrow cavity enlarged;empty bone lacunac clearly increased,and the blood sinus hemorrhage at 2 weeks after steroid injection.At the time of 3,4,5,6,7,8 weeks,the necrosis areas became larger and the fat cells proliferated and hypertrophied,and the numbers of empty bone lacunae increased.Conclusion The inject intramuscularly with methylprednisolone acetate method is simple operation and high success rate.MR imaging with STIR sequences is a high sensitive means of diagnosing pre-early osteonecrosis of the femoral head." @default.
- W2364361502 created "2016-06-24" @default.
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- W2364361502 date "2012-01-01" @default.
- W2364361502 modified "2023-09-25" @default.
- W2364361502 title "A Comparative Study of Pathological and Imageological Changes in Pre-early Steroid-induced Femoral Head Osteonecrosis of Rabbits" @default.
- W2364361502 hasPublicationYear "2012" @default.
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