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- W2364362844 abstract "Objectives To study the protective effect of exogenous melatonin (Mel) and 6-hydroxylmelatonin (6-OHMel) on neu-rons following exposure to oxygen-glucose-serum deprivation (OGSD) insults. Methods After N2a cells cultured in vitro were deprived of glucose-oxygen serum for 90 min, Mel or 6-OHMel were added to the medium. Then, the treated cells were cultured for different time. At the end of the culturing, the collected culture solution was used for the analysis of the activity of lactate dehydrogenase (LDH) and the cells were used for the examination of the cell ability, DNA fragmentation, reactive oxygen species (ROS) production, mito-chondrial transmembrane potential, cytochrome C and caspase 3 activity. Results The Mel and 6-OHMel reduced N2a cell apoptosis induced by OGSD. The inhibitory effect of Mel on the cell apoptosis was stronger than that of 6-OHMel. Both of them could inhibit LDH and cytochrome C release and caspase 3 activity. Although 6-OHMel could no longer maintain mitochondrial transmembrane potential 6 hours after OGSD, its inhibitory effect on cytochrome C release from mitochondria and the scavenging effect on ROS were stronger than those of Mel. Conclusions The protective effect of Mel and 6-OHMel on the neurons is related to their antioxidation and stabilizing mitochondrial function. The mechanism of protective effect of Mel on the neurons is more complex than that of 6-OHMel." @default.
- W2364362844 created "2016-06-24" @default.
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- W2364362844 date "2006-01-01" @default.
- W2364362844 modified "2023-09-24" @default.
- W2364362844 title "Protective Effect of Melatonin and 6-Hydroxylmelatonin on Neurons After Exposure to Oxygen-Glucose Serum Deprivation" @default.
- W2364362844 hasPublicationYear "2006" @default.
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