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- W2364363446 abstract "Objective:To study effects of different concentrations of Borrelidin on VEGF in the blood and spleen of mice as venous malformation model of oromaxillo-facial region.Methods:45 SPF male mice,aged 8weeks and weighing 25-30g,are randomly chosen as NC group.225 SPF conceived female mice were prepared as chronic bondage stress model,which weighted 25-30g.They were randomly divided into 5 groups:EX group,BO0.8 group,BO1.8 group,BO2.8 group,BO3.8 group,45/ per group.Each subgroup was randomly divided into 3 days,7 days,14 days group,15/ per group.NC group was normally raised;EX group got nothing after laparotomy.Mice spleen of different concentrations of BO groups injected with corresponding concentrations of Borrelidin.Each group was taken blood by aortic piercing operation at 3 days,7days and 14 day respectively,and then the concentrations of VEGF in different blood samples were tested using ELISA.After taking blood,expressions of VEGF in splenic tissue were tested using immunohistochemical method(SABC) and processed with pathological image quantitative analysis.Results:Concentration of VEGF in blood:trace expression in NC group;constant high expression after operation in EX group and significant statistic difference with NC group;the concentrations of VEGF in blood decreased in BO0.8,1.8,2.8,3.8 groups.The changing trend of the expression of VEGF by immunohistochemical image quantitative analysis was same as that by ELISA test.Conclusion:Borrelidin can reduce effectively the expression of VEGF in mice spleen and concentrations of VEGF in blood of venous malformation model." @default.
- W2364363446 created "2016-06-24" @default.
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- W2364363446 date "2011-01-01" @default.
- W2364363446 modified "2023-09-23" @default.
- W2364363446 title "Comparative Experimental Research about Effects of Different Concentrations of Borrelidin on VEGF in the Blood and Spleen of Mice as Venous Malformation Model of Oromaxillo-facial Region" @default.
- W2364363446 hasPublicationYear "2011" @default.
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