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- W2364368392 abstract "A mathematical description of the dose-response curve of heparin to the activated coagulation time is applied retrospectively to 20 patients treated with continuous heparin infusion. The adjusted heparin dose was compared with a calculated prediction using the theoretical mathematical model. The main actual dose was 28 U/kg/h, and the mean predicted dose was 25.8 U/kg/h. The correlation coefficient was 0.862 (p 3 0.05). These data are used to develop a dosing adjustment chart. Special considerations prior to using the calculation or dosing adjustment chart are discussed. The use of this model may allow the clinician to determine more rapidly a therapeutic heparin dosage than previous empiric approaches." @default.
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- W2364368392 date "1983-09-01" @default.
- W2364368392 modified "2023-09-26" @default.
- W2364368392 title "Adjusting Heparin Infusion Rates from the Initial Response to Activated Coagulation Time" @default.
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- W2364368392 doi "https://doi.org/10.1177/106002808301700904" @default.
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