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- W2364373575 abstract "Objective To study the protective effects of luteolin-7-O-β-D-glucopyranoside on myocardial cells injury induced by hypoxia in neonatal rats a nd to explore its mechanism. Methods The model of ischemic injury of primary cul tured myocardial cells of neonatal rats was established to investigate the effec ts of luteolin-7-O-β-D-glucopyranoside on the injury. Then lactate dehydro genase (LDH)and superoxide dismutase (SOD)malondialdehyde (MDA) were determined in each group. Cell apoptosis rate was identified by hechest33258 staining. Resu lts Luteolin-7-O-β-D-glucopyranoside (100,50 μg/mL)could increase the su rvival rate of the cells with hypoxic-ischemic injury and SOD activity,decreas e MDA content,reduce the leaking of LDH and alleviate the cell apoptosis rate. Conclusions Luteolin-7-O-β-D-glucopyranoside has protective effect on isch emic injury,which may be related to the stabilizing of cell membrane,the clear ance of oxygen free radicals and the inhibition of cell apoptosis." @default.
- W2364373575 created "2016-06-24" @default.
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- W2364373575 date "2008-01-01" @default.
- W2364373575 modified "2023-10-03" @default.
- W2364373575 title "Protective Effects of Luteolin-7-O-β-D-glucopyranoside on Hypoxic-ische mic Injury of Myocardial Cells in Neonatal Rats" @default.
- W2364373575 hasPublicationYear "2008" @default.
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