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- W2364376265 abstract "Objective To assess wh et her circulating levels of high sensitivity C-reactive protein(hs-CRP)are rel ated to essential hypertension and the effects of cilnidipine on hypertensive pa tients.Methods A total of 87 outpatients(aged from 18 to 65 ye ars)treated with cilnidipine were enrolled.The changes in serum hs-CRP concen tration,carotid intima-media thickness(IMT),intima diameter(ID)and IMT/ID ra tio compared with those before therapy were observed.The hs-CRP was determined by nephelometry and carotid IMT and ID was measured b y ultrasonography.Linear correlation analysis of the relationships between hs-CRP and blood pressure(BP),IMT,ID and IMT/ID ratio was performed.Multiple re gression analysis of relations between IMT and the risk factors,including hs-C RP,body weight index,age,blood lipids,blood glucose and course of hypertension was done.Results BP,IMT and IMT/ID were decreased and ID was in creased after cilnidipine therapy.Within 3 years,hs-CRP,IMT and IMT/ID increa sed and ID decreased with progression of hypertension,whereas hs-CRP,IMT and I MT/ID did not increase and ID did not decrese with further progression of hypert ension.The hs-CRP level,IMT and IMT/ID ratio increased with increasing systoli c blood pressure.Multiple regression analysis revealed that changes in IMT were mainly related to serum hs-CRP concentration and course of hypertension.Conclusions The results suggest that the CRP may be associated with th e development of early hypertension,and support the possible role of hypertensi on as an inflammatory stimulus contributing to vascular remodeling.Cilnidipine can improve vascular remodeling in patients with hypertension." @default.
- W2364376265 created "2016-06-24" @default.
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- W2364376265 date "2007-01-01" @default.
- W2364376265 modified "2023-09-23" @default.
- W2364376265 title "Cilnidipine on serum C-reactive protein and carotid intima-m edia thickness in hypertensive patients" @default.
- W2364376265 hasPublicationYear "2007" @default.
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