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- W2364377400 abstract "ObjectiveTo observe the antiviral activity of Ganlong Capsule against duck Hepatitis B virus(DHBV) and its protective effects on experimental liver injury in vivo.Methods(1) Experimental researches on antiviral activity of Ganlong Capsules against duck hepatitis B virus: The duck Hepatitis B model was made by injecting DHBV into the veins of one-day-old Beijing duck on the seventh day after infected by DHBV,Ganlong Capsule was given by intragastric administration for 10 days to group I(0.5 g·kg~(-1)·d~(-1)),group II(1.5 g·kg~(-1)·d~(-1)),group III(3.0!g·kg~(-1)·d~(-1)),bid×10 d,and detected the levels of DHBV-DNA in the duck blood sera obtained separately on the day before giving Ganlong Capsule,the fifth day and tenth day after giving Ganlong Capsule,and the third day after withdrawing Ganlong Capsule,by serum dot-blot hybridization.The trial was compared with acyclovor(ACV) or phosphonoformate(PFA).(2) Protective effects of Ganlong capsule on experimental liver injury in mice: Acute hepatic injury was induced by intraperitoneal injection of 0.2% CCl_4 10 ml·kg~(-1),Ganlong(200 mg·kg~(-1)) was given by intragastric or intraperitoneal administration for 2 days,bid.The serum SGPT were examined and the histopathological changes of hepatic tissue was measured.Results(1)The results of three experiments showed that the levels of sera DHBV-DNA decreased in the treatment groups of Ganlong,and in a dose-effect manner.The group III(3.0 g·kg~(-1)·d~(-1)) inhibited(P0.01) the serum DHBV-DNA significantly,and after stopping the treatment for 6 days,serum DHBV-DNA level did not return significantly,and the inhibit effects were no different,compared with the treatment group of phosphonoformate(PFA) or acyclovor(ACV).(2) Ganlong(200 mg·kg~(-1)) could obviously inhibit the increase of serum SGPT,and histological examination showed that hepatic damages of Ganlong treated mice were less severe than those of CCl_4 control group.ConclusionThese results suggested that Ganlong Capsule markedly inhibited duck hepatitis virus replication and had protective effects on experimental hepatic injury in vivo." @default.
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- W2364377400 date "2006-01-01" @default.
- W2364377400 modified "2023-09-22" @default.
- W2364377400 title "The Hepatic Pharmacological Effects of Ganlong Capsules in vivo." @default.
- W2364377400 hasPublicationYear "2006" @default.
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