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- W2364377444 abstract "Objective To evaluate the relationships among expression of p53 and pgp, chemotherapy and prognosis in advanced colorectal cancer patients.Methods 38 cases of advanced colorectal cancer patients underwent surgical operation. Immunohistochemistry was performed to detect the expression of p53 and pgp. All cases were under careful follow up.Results 23 of 38 cases were p53 positive, whereas, 18 of 38 cases were pgp positive, 10 cases showed both positive. When patients were divided into 2 groups according to preoperative chemotherapy or not (chemotherapy group vs control group), the positive rates of p53 and pgp were higher in chemotherapy group than those in control group. The local recurrence or distal metastasis was higher in both p53, pgp positive group than that in both negative group.Conclusion p53 is somewhat related to pgp. Patients who show both positive (p53 and pgp) may have poor prognosis and pgp expression may be related to chemotherapy." @default.
- W2364377444 created "2016-06-24" @default.
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- W2364377444 date "2001-01-01" @default.
- W2364377444 modified "2023-09-26" @default.
- W2364377444 title "Relationships among expression of p53 and pgp,chemotherapy and prognosis in advanced colorectal cancer patients" @default.
- W2364377444 hasPublicationYear "2001" @default.
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