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- W2364379743 abstract "Purpose To detect the expression of Nek2,Plk1 and Cdk1 in gastric carcinoma and to explore their correlation with clinicopathological factors. Methods We used immunohistochemistry to detect the protein expression of Nek2,Plk1 and Cdk1 in 80 cases of gastric carcinoma. Results The positive rates of Nek2,Plk1 and Cdk1 expressions in 80 cases of gastric carcinoma were 64%,79% and 85% respectively. While the positive rates of Nek2,Plk1 and Cdk1 expressions in 20 cases normal gastric tissue were 15%,10% and 20% respectively,with statistical significance( P 0. 01). There were significant associations between Nek2 expression and differentiation of gastric cancer,invasion depth,lymph node metastasis and TNM stage( P 0. 05). There were no significant associations between Nek2 expression and age,gender and tumor size( P 0. 05). The expression of Plk1 and Cdk1 had a correlation with tumor size,differentiation of gastric cancer,invasion depth,lymph node metastasis and TNM stage( P 0. 05). There were no significant associations between Plk1 and Cdk1 expressions and age and tumor size( P 0. 05). There were significant associations between Nek2 and Plk1,Plk1 and Cdk1,Nek2 and Cdk1 expression( P 0. 01). Conclusions Abnormal expression of Nek2,Plk1 and Cdk1 might be one of the mechanisms of tumorigenesis,especially of abnormal tumour proliferation. They may represent new potential targets for therapeutic intervention." @default.
- W2364379743 created "2016-06-24" @default.
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- W2364379743 date "2014-01-01" @default.
- W2364379743 modified "2023-09-25" @default.
- W2364379743 title "Expression of Nek2,Plk1 and Cdk1 in gastric carcinoma and their clinicopathological significance" @default.
- W2364379743 hasPublicationYear "2014" @default.
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