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- W2364382203 abstract "Objective:To assess the efficacy and safety of combination tamsulosin with solifenacin in treatment of benign prostatic hyperplasia(BPH) patients with overactive bladder(OAB). Method:262 cases were included and were randomly divided into the trial group(134 cases) and control group(128 cases).Patients in trial group were administrated with tamsulosin at 0.2 mg and solifenacin at 5mg once daily for 4 weeks.Patients in control group were administrated only with tamsulosin at 0.2mg once daily for 4 weeks.The efficacy and safety of treatment were assessed by changes before and after treatment in subjective outcome measures including IPSS,OABSS,QOL and objective outcome measures including Qmax,daily frequency of micturition,urgency,urgency incontinence,nocturia,voiding volumes. Result:There are significant differences in subjective and objective outcome measures in two groups between before and after treatment(P0.05).Moreover,there are significant differences in changes before and after treatment of subjective and objective outcome measures except for Qmax and voiding volumes(P0.05).There are no significant difference in the changes before and after treatment of Qmax and voiding volumes(P0.05).The total incidences of adverse events in trial group and control group are 4.58% and 2.47% respectively,and no severe adverse event happens. Conclusion:Combination tamsulosin with solifenacin in treatment of benign prostatic BPH patients with OAB has better efficacy than tamsulosin only,nevertheless,has good safety." @default.
- W2364382203 created "2016-06-24" @default.
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- W2364382203 date "2012-01-01" @default.
- W2364382203 modified "2023-09-25" @default.
- W2364382203 title "Efficacy and safety of combination tamsulosin with solifenacin in treatment of benign prostatic hyperplasia with overactive bladder" @default.
- W2364382203 hasPublicationYear "2012" @default.
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