Matches in SemOpenAlex for { <https://semopenalex.org/work/W2364384203> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2364384203 abstract "Objective To investigate the role of Vitamin C as a sensitizer for arsenic trioxide in epithelial ovarian cancer cells and the apoptotic mechanisms. Methods In OVCAR-3 cells, the anti-cancer effects were observed when Vitamin C or AS2O3 was given alone, and the sensitizing effects of Vitamin C were observed when it was used in the combination with arsenic trioxide. MTT chemosensitivity test, Flow Cytometry for examination of apoptosis and cell cycle status and Western-blot were applied. Results Dose-dependent antiproliferative effect on epithelial ovarian cancer cell lines was observed when Vitamin C or AS2O3 was applied as single agent, the IC50 value was 4.72 μmol/L and 21.85μmol/L respectively. When the two agents were applied simultaneously, the growth inhibition rate was significantly higher than that of the group treated with AS2O3 alone, and the P value of the two combined regimen experiments were 0.001, 0.012 respectively, the q value of the combined effects was 2.71, 1.63 respectively.These results showed synergistic effect of the two agents. Flow Cytometry testing showed significant S phase block and increased apoptosis rate in the combination treatment group. In Western-blot experiments, Bcl-2 expression of the combination treatment group was down-regulated,and Bax expression was up-regulated compared with the group treated by AS2O3 alone. Conclusion Vitamin C has sensitizing effect on arsenic trioxide in the treatment of epithelial ovarian cancer cell lines, which should be promising in the further study." @default.
- W2364384203 created "2016-06-24" @default.
- W2364384203 creator A5058843102 @default.
- W2364384203 date "2014-01-01" @default.
- W2364384203 modified "2023-09-24" @default.
- W2364384203 title "Role of Vitamin C as a sensitizer for arsenic trioxide in epithelial ovarian cancer cells" @default.
- W2364384203 hasPublicationYear "2014" @default.
- W2364384203 type Work @default.
- W2364384203 sameAs 2364384203 @default.
- W2364384203 citedByCount "0" @default.
- W2364384203 crossrefType "journal-article" @default.
- W2364384203 hasAuthorship W2364384203A5058843102 @default.
- W2364384203 hasConcept C104317684 @default.
- W2364384203 hasConcept C121608353 @default.
- W2364384203 hasConcept C126322002 @default.
- W2364384203 hasConcept C153911025 @default.
- W2364384203 hasConcept C185592680 @default.
- W2364384203 hasConcept C190283241 @default.
- W2364384203 hasConcept C203014093 @default.
- W2364384203 hasConcept C2776415932 @default.
- W2364384203 hasConcept C2776940978 @default.
- W2364384203 hasConcept C2780022331 @default.
- W2364384203 hasConcept C2780386689 @default.
- W2364384203 hasConcept C29537977 @default.
- W2364384203 hasConcept C502942594 @default.
- W2364384203 hasConcept C553184892 @default.
- W2364384203 hasConcept C55493867 @default.
- W2364384203 hasConcept C71924100 @default.
- W2364384203 hasConcept C86803240 @default.
- W2364384203 hasConceptScore W2364384203C104317684 @default.
- W2364384203 hasConceptScore W2364384203C121608353 @default.
- W2364384203 hasConceptScore W2364384203C126322002 @default.
- W2364384203 hasConceptScore W2364384203C153911025 @default.
- W2364384203 hasConceptScore W2364384203C185592680 @default.
- W2364384203 hasConceptScore W2364384203C190283241 @default.
- W2364384203 hasConceptScore W2364384203C203014093 @default.
- W2364384203 hasConceptScore W2364384203C2776415932 @default.
- W2364384203 hasConceptScore W2364384203C2776940978 @default.
- W2364384203 hasConceptScore W2364384203C2780022331 @default.
- W2364384203 hasConceptScore W2364384203C2780386689 @default.
- W2364384203 hasConceptScore W2364384203C29537977 @default.
- W2364384203 hasConceptScore W2364384203C502942594 @default.
- W2364384203 hasConceptScore W2364384203C553184892 @default.
- W2364384203 hasConceptScore W2364384203C55493867 @default.
- W2364384203 hasConceptScore W2364384203C71924100 @default.
- W2364384203 hasConceptScore W2364384203C86803240 @default.
- W2364384203 hasLocation W23643842031 @default.
- W2364384203 hasOpenAccess W2364384203 @default.
- W2364384203 hasPrimaryLocation W23643842031 @default.
- W2364384203 hasRelatedWork W2016300460 @default.
- W2364384203 hasRelatedWork W2030385954 @default.
- W2364384203 hasRelatedWork W2348329566 @default.
- W2364384203 hasRelatedWork W2350608842 @default.
- W2364384203 hasRelatedWork W2350876648 @default.
- W2364384203 hasRelatedWork W2355798177 @default.
- W2364384203 hasRelatedWork W2362378512 @default.
- W2364384203 hasRelatedWork W2364018395 @default.
- W2364384203 hasRelatedWork W2364275346 @default.
- W2364384203 hasRelatedWork W2369421751 @default.
- W2364384203 hasRelatedWork W2369448908 @default.
- W2364384203 hasRelatedWork W2370356849 @default.
- W2364384203 hasRelatedWork W2370544140 @default.
- W2364384203 hasRelatedWork W2378609257 @default.
- W2364384203 hasRelatedWork W2381951155 @default.
- W2364384203 hasRelatedWork W2387242230 @default.
- W2364384203 hasRelatedWork W2390560723 @default.
- W2364384203 hasRelatedWork W2391058056 @default.
- W2364384203 hasRelatedWork W2394353886 @default.
- W2364384203 hasRelatedWork W2412405619 @default.
- W2364384203 isParatext "false" @default.
- W2364384203 isRetracted "false" @default.
- W2364384203 magId "2364384203" @default.
- W2364384203 workType "article" @default.