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- W2364385259 abstract "Objective:To investigate the association of genetic polymorphisms of CHRNA4,CHRNA7 with Sporadic Alzheimer' disease. Methods:In 23 Sporadic Alzheimer' disease (SAD) patients and 30 cases of normal control,exon3 of CHRNA4 was screened by PCR-DGGE and sequencing. In 16 Sporadic Alzheimer' disease (SAD) patients and 16 cases of normalcontrol,all exon and parts of intron of CHRNA7 were screened by PCR-DGGE and DNA sequencing. Results:CHRNA4 of three genetic polymorphisms were found in the AD and the control group: C 104T (2=8.41 ,P0.05 ),A 136G (2=16.21 ,P0.05),G169A (2=3.98,P0.05) . CHRNA7 of two genetic polymorphisms were found in the AD and the control group: G 3133418 C (2=4.571,P0. 05) ,117643+ GTG inserted (2=1.032,P0. 5) Conclusions: These three genetic polymorphisms may be associated with pathogenesis of SAD,since there is statistical difference between the AD and control group. These polymorphisms may be associated with Sporadic Alzheimer' disease" @default.
- W2364385259 created "2016-06-24" @default.
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- W2364385259 date "2006-01-01" @default.
- W2364385259 modified "2023-09-23" @default.
- W2364385259 title "Association of genetic polymorphisms of CHRNA4 ,7 with Sporadic Alzheimer's disease" @default.
- W2364385259 hasPublicationYear "2006" @default.
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