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- W2364387650 abstract "AIM: To observe the induction of osteoprotegerin ligand in the differentiation and function of osteoclasts derived from mouse peripheral blood monocytes (PBMCs). METHODS: After the mouse PBMCs were isolated and cultured in wells, which contained glass coverslips and ivory dentine slices, macrophage colony stimulating factor (M CSF) and osteoprotegerin ligand (OPGL) were added. Dexamethasone was also added in the wells of Group B but not Group A. When the multinuclear cells were observed in the culture, the coverslips were stopped and stained for tartrate resistant acid phosphatase (TRAP). Seven days after the stop of coverslips, the dentine slices were stopped and stained for toluidine blue to observe bone resorption by osteoclasts, and the areas of bone resorption were analyzed by computer. RESULTS: After 7 or 10 days culture of PBMCs, plenty of large multinuclear cells could be found on the coverslips and in the wells of Group B, the formation of multinuclear cells was seen earlier than Group A. Most of multinuclear cells were TRAP positive and most of monocytes and macrophages were negative or weakly positive. Bone resorption was observed on the dentine slices and the statistic analysis did not show any significant difference between different groups ( P 0.05). CONCLUSION: Cultured with OPGL, mouse PBMCs can differentiate into osteoclasts and induce bone resorption on dentine slices. It seems that dexamethasone can accelerate the formation of osteoclasts but it has no effects on bone resorption by osteoclasts." @default.
- W2364387650 created "2016-06-24" @default.
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- W2364387650 date "2003-01-01" @default.
- W2364387650 modified "2023-09-27" @default.
- W2364387650 title "Observation of the formation and function of osteoclasts derived from mouse peripheral blood monocytes induced by osteoprotegerin ligand" @default.
- W2364387650 hasPublicationYear "2003" @default.
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