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- W2364392695 abstract "Objective To synthesize and identify the biodegradable block copolymers.Methods Biodegradable block copolymers PLGA-PEG-PLGA were synthesized using successive ring opening polymerization of PEG 1000,PEG 1500 or their mixture(m∶m=1∶1),dl-lactide and glycolide.The structural characteristics of copolymers were identified by means of DSC,GPC and (()~1H-NMR).Results The result show that products were block copolymers.Their number-average molecular weights were calculated through the methods of DSC,GPC and (()~1H-NMR).The aqueous solutions of PLGA-PEG-PLGA polymers have reverse thermal gelation properties.The phase transition temperature(from liquid to hydrogel)of 30%(PLGA-PEG-PLGA(3))was (33 ℃),whick is consistent with body temperature.Conclusions A new kind of carrier materials of biodegradable drugs is provided." @default.
- W2364392695 created "2016-06-24" @default.
- W2364392695 creator A5050173786 @default.
- W2364392695 date "2005-01-01" @default.
- W2364392695 modified "2023-09-23" @default.
- W2364392695 title "Synthesis and characterization of biodegradable block copolymers of PLGA-PEG-PLGA" @default.
- W2364392695 hasPublicationYear "2005" @default.
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