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- W2364396073 abstract "Objective:To investigate the anti tumor immunity induced by tumor derived heat shock protein70(HSP70) and provide useful information for HSP70 administration to treat human cancers.Methods:Purified HSP70 was prepared from tumor by cell culture protein extraction and purification,SDS PAGE,Western blot and animal experiment were applied for HSP70 analysis.Results:100% mice received HSP70 10 μg immunization survived over 90 days and the implanted tumors were eradicated.The mice vaccinated with 5 μg HSP70 survived for averaged 28.2±4.8 days,but none of this group obtained long period survival.Significance was found in both these groups when contrasted with control group whose averaged survival period was only 18.3±3.6 days.To the tumor bearing mice,5 μg HSP70 administration showed partial therapeutic efficacy,the averaged survival period was 31.3±2.9 days,but the mice treated with 10 μg HSP70 survived over 58.8± 33.7 days,and 40% of the mice in this group got long period tumor free survival(90 days),obvious difference( P 0.01) observed when contrasted with the other groups.Conclusion:Tumor derived HPS70 can induce powerful anti tumor immune efficacy and have favorable therapeutic efficacy,which offered significant information for HSP70 application to fight human cancers." @default.
- W2364396073 created "2016-06-24" @default.
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- W2364396073 date "2003-01-01" @default.
- W2364396073 modified "2023-09-25" @default.
- W2364396073 title "Study on the anti-tumor immune efficacy of tumor-derived heat shock protein70" @default.
- W2364396073 hasPublicationYear "2003" @default.
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