FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2364396948> ?p ?o ?g. }

• W2364396948 abstract "Multiple sclerosis (MS) is generally known as a manageable but not yet curable autoimmune disease affecting central nervous system. A potential therapeutic approach should possess several properties: Prevent immune system from damaging the brain and spinal cord, promote differentiation of oligodendrocyte progenitor cells (OPCs) into mature oligodendrocytes to produce myelin, prevent the formation of fibronectin aggregates by astrocytes to inhibit scar formation, and enhance function of healthy endothelial cells (ECs).To determine if an increase in sulfur contents through H2S, a potent antioxidant known to induce protective autophagy in cells, could provide the above desired outcomes, peripheral blood mononuclear cells (PBMNCs), OCPs, astrocytes, and ECs were treated with NaHS (50 μM) in vitro.Transmigration assay using EC monolayer showed that serotonin increased migration of PBMNC while pretreatment of EC with NaHS inhibited the migration induced by serotonin treatment. NaHS upregulated proteins involved in immune system response and downregulated PBMNCs- and EC-related adhesion molecules (LFA-1 and VCAM-1). Furthermore, it had a cell expansion inducing effect, altering EC morphology. The effects of NaHS on OPCs and astrocytes were studied compared to mTOR inhibitor rapamycin. In NaHS treated astrocytes the induced fibronectin production was partially inhibited while rapamycin almost fully inhibited fibronectin production. NaHS slowed but did not inhibit the differentiation of OCPs or the production of myelin compared to rapamycin.The in vitro results point to the potential therapeutic application of hydrogen sulfide releasing molecules or health-promoting sulfur compounds in MS." @default.
• W2364396948 created "2016-06-24" @default.
• W2364396948 creator A5057759317 @default.
• W2364396948 date "2016-01-01" @default.
• W2364396948 modified "2023-10-17" @default.
• W2364396948 title "Pathophysiological Concepts in Multiple Sclerosis and the Therapeutic Effects of Hydrogen Sulfide" @default.
• W2364396948 cites W1503511302 @default.
• W2364396948 cites W1508323668 @default.
• W2364396948 cites W1514528045 @default.
• W2364396948 cites W1516260708 @default.
• W2364396948 cites W1607206274 @default.
• W2364396948 cites W1655368476 @default.
• W2364396948 cites W1971634147 @default.
• W2364396948 cites W1971777946 @default.
• W2364396948 cites W1974745131 @default.
• W2364396948 cites W1981050866 @default.
• W2364396948 cites W1982204079 @default.
• W2364396948 cites W1985864706 @default.
• W2364396948 cites W1987062630 @default.
• W2364396948 cites W1988002224 @default.
• W2364396948 cites W1988149915 @default.
• W2364396948 cites W1994049385 @default.
• W2364396948 cites W1999489242 @default.
• W2364396948 cites W2001420609 @default.
• W2364396948 cites W2005350671 @default.
• W2364396948 cites W2006512241 @default.
• W2364396948 cites W2008697475 @default.
• W2364396948 cites W2009327693 @default.
• W2364396948 cites W2010281862 @default.
• W2364396948 cites W2023506785 @default.
• W2364396948 cites W2026460136 @default.
• W2364396948 cites W2026688064 @default.
• W2364396948 cites W2028370526 @default.
• W2364396948 cites W2034878292 @default.
• W2364396948 cites W2035934190 @default.
• W2364396948 cites W2037265282 @default.
• W2364396948 cites W2040322783 @default.
• W2364396948 cites W2048082433 @default.
• W2364396948 cites W2048354944 @default.
• W2364396948 cites W2050179299 @default.
• W2364396948 cites W2053670265 @default.
• W2364396948 cites W2056505450 @default.
• W2364396948 cites W2063454260 @default.
• W2364396948 cites W2069950190 @default.
• W2364396948 cites W2076991119 @default.
• W2364396948 cites W2077116768 @default.
• W2364396948 cites W2078297463 @default.
• W2364396948 cites W2086610416 @default.
• W2364396948 cites W2090481297 @default.
• W2364396948 cites W2095355384 @default.
• W2364396948 cites W2100352143 @default.
• W2364396948 cites W2102828742 @default.
• W2364396948 cites W2104625197 @default.
• W2364396948 cites W2111379723 @default.
• W2364396948 cites W2112682556 @default.
• W2364396948 cites W2114966729 @default.
• W2364396948 cites W2119979092 @default.
• W2364396948 cites W2120798493 @default.
• W2364396948 cites W2122438668 @default.
• W2364396948 cites W2123913783 @default.
• W2364396948 cites W2127137398 @default.
• W2364396948 cites W2128246464 @default.
• W2364396948 cites W2128635872 @default.
• W2364396948 cites W2130868298 @default.
• W2364396948 cites W2132586074 @default.
• W2364396948 cites W2136113015 @default.
• W2364396948 cites W2140777557 @default.
• W2364396948 cites W2145612190 @default.
• W2364396948 cites W2160422154 @default.
• W2364396948 cites W2163117312 @default.
• W2364396948 cites W2163365522 @default.
• W2364396948 cites W2167617896 @default.
• W2364396948 cites W2171125850 @default.
• W2364396948 doi "https://doi.org/10.15412/j.bcn.03070206" @default.
• W2364396948 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4892317" @default.
• W2364396948 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27303607" @default.
• W2364396948 hasPublicationYear "2016" @default.
• W2364396948 type Work @default.
• W2364396948 sameAs 2364396948 @default.
• W2364396948 citedByCount "7" @default.
• W2364396948 countsByYear W23643969482017 @default.
• W2364396948 countsByYear W23643969482018 @default.
• W2364396948 countsByYear W23643969482020 @default.
• W2364396948 countsByYear W23643969482023 @default.
• W2364396948 crossrefType "journal-article" @default.
• W2364396948 hasAuthorship W2364396948A5057759317 @default.
• W2364396948 hasBestOaLocation W23643969481 @default.
• W2364396948 hasConcept C1491633281 @default.
• W2364396948 hasConcept C169760540 @default.
• W2364396948 hasConcept C185592680 @default.
• W2364396948 hasConcept C202751555 @default.
• W2364396948 hasConcept C203014093 @default.
• W2364396948 hasConcept C2776914184 @default.
• W2364396948 hasConcept C2778486448 @default.
• W2364396948 hasConcept C2779965356 @default.
• W2364396948 hasConcept C2780640218 @default.
• W2364396948 hasConcept C529278444 @default.
• W2364396948 hasConcept C55493867 @default.
• W2364396948 hasConcept C62478195 @default.
• W2364396948 hasConcept C86492073 @default.

• next