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- W2364398002 abstract "AIM: To investigate the apoptosis of human osteoblastic h FOB 1. 19 cells induced by sonicated extract of P. endodontalis and the relevant molecular mechanism. METHODS: After exposure to sonicated extract of P. endodontalis at 0( the control),1,10 and 100 μg / m L for 48 h,the morphology changes of h FOB 1. 19 cells were observed by Hoechst33258 staining. Caspase-3 activity was detected by colorimetric assay. The apoptosis rate was analyzed by flow cytometry after the cells had been treated with the extract of P. endodontalis plus Caspase inhibitors. RESULTS: The sonicated extract of P. endodontalis induced chromatin concentration,breakup and other typical apoptosis changes in h FOB 1. 19 cells. Meanwhile,the extract increased Caspase-3 activity of h FOB 1. 19 cells in a dose- dependent manner( P 0. 05) Caspase- 8 inhibitor and Caspase-9 inhibitor partially inhibited the apoptosis of h FOB 1.19 cells induced by the extract. Caspase-3 inhibitor completely blocked the apoptosis of h FOB 1. 19 cells. CONCLUSION: The extract of P. endodontalis can promote h FOB 1. 19 cell apoptosis. Caspase-3-dependent apoptosis pathway is involved in this process,including both internal and external pathway." @default.
- W2364398002 created "2016-06-24" @default.
- W2364398002 creator A5066326754 @default.
- W2364398002 date "2014-01-01" @default.
- W2364398002 modified "2023-09-26" @default.
- W2364398002 title "Preliminary study on the mechanism of osteoblast apoptosis induced by Porphyromonas endodontalis" @default.
- W2364398002 hasPublicationYear "2014" @default.
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