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- W2364400852 abstract "Objective:To investigate the effect of Longma Jinning Decoction on expressions of PKBm RNA and α-SMAm RNA in lung tissues of asthma rats. Methods:Totally 70 male SD rats were randomized into 7 groups,10 in each. We copied the ovalbumin sensitizde and LPS stimulation in rat asthma model. 21 days after modeling,normal and model control groups were given the same amount of distillde water every day. The dexamethasone group,Maxing Shigan Decoction group and high,medium,low dose groups of Longma Jinning Decoction were given the corresponding drugs according to human and rat body surface area ratio. The lung histopathology changes were observed by HE staining. Immunohistochemistry method was used to observe I and III collagen in the lungs' small airway. Enzyme-linked immunosorbent assay method was used to observe espression of platelet derived growth factor(PDGF). Expressions of α-SMAm RNA and PKBm RNA in the lungs at m RNA levels were detected by RT-PCR. Results:The model group had the obvious lung organization inflammation response and the gas channel restructuring phenomenon. Compared with those of the normal group,its PKBm RNA,A-SMAm RNA,PDGF and I and III collagen levels were more increased(P0.01). The treatment group had the varying degree change compared with the model group. The PKBm RNA,α-SMAm RNA,PDGF and I and III collagen levels were decreased than those of the model group(P0.01). Conclusion:These results suggest that Longma Jinning Decotion may effectively alleviate airway inflammation and reverse the airway remodeling and inhibit the expressions of PKB,α-SMA,PDGF and I and III collagen." @default.
- W2364400852 created "2016-06-24" @default.
- W2364400852 creator A5011057742 @default.
- W2364400852 date "2015-01-01" @default.
- W2364400852 modified "2023-09-22" @default.
- W2364400852 title "Effect of Longma Jinning Decoction on Expressions of PKBm RNA and α-SAMm RNA in Lung Tissues of Asthma Rats" @default.
- W2364400852 hasPublicationYear "2015" @default.
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