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- W2364402937 abstract "Aim To study the inhibitory effect of oxidized low density lipoprotein (ox-LDL) on the expression of caveolin-1 in vascular smooth muscle cell (SMC) and its relation with extracellular-signal regulated kinases 1/2 (ERK1/2). Methods Western blot was performed to evaluate the effects of ox-LDL (50 mg/L) or ox-LDL (50 mg/L) and PD98059 (25 μmol/L) on expression of caveolin-1and ERK1/2 in vascular SMC in different times. Results Ox-LDL (50 mg/L) obviously decreased caveolin-1 expression, and significantly increased ERK1/2 phosphorylation activity. However, the activation of ERK1/2 blocked by PD98059 significantly promoted caveolin-1 expression. Conclusions Downregulation of caveolin-1 expression in foam cell derived from vascular smooth muscle cell is involved in ERK1/2 phosphorylation activity and its signaling pathway activated by ox-LDL." @default.
- W2364402937 created "2016-06-24" @default.
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- W2364402937 date "2007-01-01" @default.
- W2364402937 modified "2023-09-27" @default.
- W2364402937 title "The Inhibitory Effect of Oxidized Low Density Lipoprotein on the Expression of Caveolin-1 in Vascular Smooth Muscle Cell and Its Relation with Extracellular-signal Regulated Kinases 1/2" @default.
- W2364402937 hasPublicationYear "2007" @default.
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