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- W2364403574 abstract "AIM: To observe changes of intracellular free calcium levels([Ca~(2+)]i) and neuroglobin(NGB) expression when rats′ brain cells were exposed to chemical hypoxia,and the influence of aspirin(ASA) on changes as well as to study its mechanism primarily.METHODS: Sodium dihionite was used to deprive the oxygen in culture medium,and confocal laser scanning microscope with double fluorescence labeling methods were used to measure the changes of [Ca~(2+)]i and NGB expression in rats′ brain cells.Flou-3/AM and Cy-3 were used to indicate calcium concentration and NGB expression respectively.RESULTS: [Ca~(2+)]i and NGB expression are related to the time of hypoxia.Compared with the normal control group,average fluorescent intensity of [Ca~(2+)]i and NGB expression in the simple hypoxia group increased gradually with the time of the exposure in hypoxia.Moreover,there is the positive correlation between [Ca~(2+)]i and NGB expression.[Ca~(2+)]i and NGB expression in the ASA pretreated group increased slowly,the increase degree is significantly lower than that in the simple hypoxia group.[Ca~(2+)]i and NGB expression in the ASA treated group were increased significantly in early stage,the increase degree is not significant diffexence from the simple hypoxia group.At 120 min,[Ca~(2+)]i and NGB expression in the ASA treated group increased slowly,the increase degree is significantly lower than that in the simple hypoxia group.CONCLUSION: ASA has a protective effect on hypoxic injury of rats′ brain cells,which may be attribute to its inhibiting calcium overload,and NGB expression is regulated by Ca2+-CaM complex.In addition,the neuroprotective effects of ASA pretreated group were better than ASA treated group in early stage." @default.
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- W2364403574 date "2008-01-01" @default.
- W2364403574 modified "2023-09-23" @default.
- W2364403574 title "Chemical hypoxia induced [Ca~(2+)]_i and NGB alteration and aspirin intervention" @default.
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