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- W2364407575 abstract "Many studies have shown that low density lipoprotein (LDL) can be oxidatively modified in various ways and the rate of degradation of these oxidized LDL by macrophages can be 3 to 10 times faster than that of native LDL. This process may be important in the formation of cholesterol-laden foam cells derived from macrophages in atherosclerotic lesions. In this study, China green tea polyphenol (CGTP, 10 μg·ml-1) and morin (8.5 μg ·ml-1), one kind of flavonoids, were used as the inhibitors of LDL oxidative modification caused by ultraviolet ray (uv) irradiation and CuSO4. The agarose gel electrophoresis mobility, the level of thiobarbituric acid reactive substance and the fluorescence emission spectra at 360nm excitation as well as the degradation rate by mouse peritoneal macrophages were observed. The results show that both CGTP and morin are the potent inhibitors of the oxidative modification of LDL. These findings afford the possibility that both CGTP and morin may protect LDL from oxidation, prevent and alleviate the atherosclerotic development and may therefore be the effective natural anti-atherosclerotic components." @default.
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- W2364407575 date "1992-01-01" @default.
- W2364407575 modified "2023-09-23" @default.
- W2364407575 title "Inhibitory effect of green tea polyphenol and morin on the oxidative modification of low density lipoprotein" @default.
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