Matches in SemOpenAlex for { <https://semopenalex.org/work/W2364408804> ?p ?o ?g. }
- W2364408804 endingPage "G141" @default.
- W2364408804 startingPage "G130" @default.
- W2364408804 abstract "Despite increased appreciation for the role of nicotinic receptors in the modulation of and response to inflammation, the contribution of muscarinic receptors to mucosal homeostasis, clearance of enteric pathogens, and modulation of immune cell function remains relatively undefined. Uninfected and Nippostrongylus brasiliensis-infected wild-type and type 3 muscarinic receptor (M3R)-deficient ( Chrm3 −/− ) mice were studied to determine the contribution of M3R to mucosal homeostasis as well as host defense against the T H 2-eliciting enteric nematode N. brasiliensis. Intestinal permeability and expression of T H 1/T H 17 cytokines were increased in uninfected Chrm3 −/− small intestine. Notably, in Chrm3 −/− mice infected with N. brasiliensis, small intestinal upregulation of T H 2 cytokines was attenuated and nematode clearance was delayed. In Chrm3 −/− mice, T H 2-dependent changes in small intestinal function including smooth muscle hypercontractility, increased epithelial permeability, decreased epithelial secretion and absorption, and goblet cell expansion were absent despite N. brasiliensis infection. These findings identify an important role for M3R in host defense and clearance of N. brasiliensis, and support the expanding role of cholinergic muscarinic receptors in maintaining mucosal homeostasis." @default.
- W2364408804 created "2016-06-24" @default.
- W2364408804 creator A5005329195 @default.
- W2364408804 creator A5016656665 @default.
- W2364408804 creator A5021851349 @default.
- W2364408804 creator A5023306685 @default.
- W2364408804 creator A5033807136 @default.
- W2364408804 creator A5042622786 @default.
- W2364408804 creator A5044085157 @default.
- W2364408804 creator A5046243234 @default.
- W2364408804 creator A5086548147 @default.
- W2364408804 creator A5090807587 @default.
- W2364408804 date "2016-07-01" @default.
- W2364408804 modified "2023-10-16" @default.
- W2364408804 title "Type 3 muscarinic receptors contribute to intestinal mucosal homeostasis and clearance of <i>Nippostrongylus brasiliensis</i> through induction of T<sub>H</sub>2 cytokines" @default.
- W2364408804 cites W1543204600 @default.
- W2364408804 cites W1557979114 @default.
- W2364408804 cites W1573354163 @default.
- W2364408804 cites W170751245 @default.
- W2364408804 cites W1828221682 @default.
- W2364408804 cites W1864629760 @default.
- W2364408804 cites W1905645331 @default.
- W2364408804 cites W1938705645 @default.
- W2364408804 cites W1944128994 @default.
- W2364408804 cites W1972899659 @default.
- W2364408804 cites W1981409699 @default.
- W2364408804 cites W1982746655 @default.
- W2364408804 cites W1986367298 @default.
- W2364408804 cites W1988970114 @default.
- W2364408804 cites W1992664508 @default.
- W2364408804 cites W2003084688 @default.
- W2364408804 cites W2007252917 @default.
- W2364408804 cites W2008873185 @default.
- W2364408804 cites W2008949228 @default.
- W2364408804 cites W2011671647 @default.
- W2364408804 cites W2015815276 @default.
- W2364408804 cites W2016451329 @default.
- W2364408804 cites W2024755684 @default.
- W2364408804 cites W2026222659 @default.
- W2364408804 cites W2035764211 @default.
- W2364408804 cites W2039537787 @default.
- W2364408804 cites W2039579271 @default.
- W2364408804 cites W2039901999 @default.
- W2364408804 cites W2042207589 @default.
- W2364408804 cites W2046775696 @default.
- W2364408804 cites W2054366648 @default.
- W2364408804 cites W2054562186 @default.
- W2364408804 cites W2058939956 @default.
- W2364408804 cites W2059032518 @default.
- W2364408804 cites W2059699981 @default.
- W2364408804 cites W2067710368 @default.
- W2364408804 cites W2069368135 @default.
- W2364408804 cites W2069568470 @default.
- W2364408804 cites W2073295417 @default.
- W2364408804 cites W2074267727 @default.
- W2364408804 cites W2086733370 @default.
- W2364408804 cites W2093237038 @default.
- W2364408804 cites W2094601449 @default.
- W2364408804 cites W2095668015 @default.
- W2364408804 cites W2098615045 @default.
- W2364408804 cites W2098655301 @default.
- W2364408804 cites W2103879926 @default.
- W2364408804 cites W2104838343 @default.
- W2364408804 cites W2107665224 @default.
- W2364408804 cites W2110015632 @default.
- W2364408804 cites W2113743453 @default.
- W2364408804 cites W2119924555 @default.
- W2364408804 cites W2122206264 @default.
- W2364408804 cites W2127379971 @default.
- W2364408804 cites W2129324944 @default.
- W2364408804 cites W2139252469 @default.
- W2364408804 cites W2139712080 @default.
- W2364408804 cites W2140076954 @default.
- W2364408804 cites W2152380899 @default.
- W2364408804 cites W2156595997 @default.
- W2364408804 cites W2156897641 @default.
- W2364408804 cites W2157843593 @default.
- W2364408804 cites W2158445295 @default.
- W2364408804 cites W2158928937 @default.
- W2364408804 cites W2165658685 @default.
- W2364408804 cites W2321862627 @default.
- W2364408804 cites W2404362072 @default.
- W2364408804 doi "https://doi.org/10.1152/ajpgi.00461.2014" @default.
- W2364408804 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4967171" @default.
- W2364408804 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27173511" @default.
- W2364408804 hasPublicationYear "2016" @default.
- W2364408804 type Work @default.
- W2364408804 sameAs 2364408804 @default.
- W2364408804 citedByCount "30" @default.
- W2364408804 countsByYear W23644088042017 @default.
- W2364408804 countsByYear W23644088042018 @default.
- W2364408804 countsByYear W23644088042019 @default.
- W2364408804 countsByYear W23644088042020 @default.
- W2364408804 countsByYear W23644088042021 @default.
- W2364408804 countsByYear W23644088042022 @default.
- W2364408804 countsByYear W23644088042023 @default.
- W2364408804 crossrefType "journal-article" @default.
- W2364408804 hasAuthorship W2364408804A5005329195 @default.