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- W2364422018 abstract "By using Chinese adult liver samples. themetabolism of diazepam was studied in the Chinese livermicrosomes. The studies show that nordiazepam andtemazepam are the major products of diazepam metabolism.There are a high-affinity component and a low-affinity com-ponent of the enzymes for each metabolic pathway ofdiazepam. With the substrate in pmol. Lconcentration em-ployed in studies in vitro, the metabolism of diazepam may bemediated primarily by forms of cytochrome P450 with lowKn and high Vmax characteristics. Debrisoquine, quinidine,mephenytoin, phenytoin all had no significant effects ondiazepam metabolism in vitro in Chinese liver microsomes, in-dicating that diazcpam metabolism may not cosegregate withdebrisoquine or Smephenytoin polymorphic hydroxylationin Chinese subXcts. But omeprazole, whose metabolismcosegregates with that of Smephenytoin in both Chinese andCaucasian, and propranolol, whose elimination is related tothe polymorphic metabolisms of hoth debrisoquine andSmephenytoin, could competitively or noncornpetitively in-hibit the N-demethylation and C3-hydroxylation ofdiazepam. On the contrary, methaqualone could activate boththe metabolic pathways of diazepam in Chinese livermicrosomes." @default.
- W2364422018 created "2016-06-24" @default.
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- W2364422018 date "1995-01-01" @default.
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- W2364422018 title "Metabolism of diazepam in Chinese adult liver microsomes" @default.
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