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- W2364425913 abstract "Objective To establish RGC-5 cell damage model induced by H2O2,and to observe the protective effect of different dose of ginsenoside Rb1 on RGC-5 apoptosis induced by H2O2 and find the possible mechanisms of the neuroprotection. Methods MTT was used to detect the effect of different dose of ginsenoside Rb1 on RGC-5 activity induced by H2O2. SOD and GSH were detected by Kit method,and PI,Caspase-3,Ca2 +were detected by immunofluorescence chemical dyeing method. Results A,B,C,D,E groups at 490 nm for detection of cell viability were 0. 266 ± 0. 038,0. 299± 0. 025,0. 314 ± 0. 014,0. 222 ± 0. 031,0. 391 ± 0. 041,A,B,C,E group compared with D group,all P 0. 05. The control group,the experimental group,model group,SOD content were 19. 88 ± 0. 12,17. 12 ± 0. 32,15. 47 ± 0. 21,and experimental group,control group were compared with the model group,all P 0. 05. Experimental group and control group,model group,GSH content were 15. 67 ± 0. 18 and 14. 98 ± 0. 25,13. 71 ± 0. 31,and the experimental group and the control group were compared with the model group,all P 0. 05. Compared with the model group,the experimental groups decreased Caspase-3 expression,suggesting that the 0. 1 m M of ginsenoside Rb1 can significantly inhibit the expression of Caspase-3. PI staining cells increased significantly in the model group,RGC-5 was obviously injured by H2O2 which lead to cell death. Apoptosis of cells were decreased in experimental group. Ca2 +increased obviously in model group.Ca2 +were significantly decreased in experimental group. Conclusion Ginsenosides Rb1 can prevent RGC-5 death induced by H2O2. The mechanism may be related to up-regulate SOD,GSH activity and reduce the activity of apoptosis-related proteins Caspase-3 and Ca2 +." @default.
- W2364425913 created "2016-06-24" @default.
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- W2364425913 date "2014-01-01" @default.
- W2364425913 modified "2023-09-28" @default.
- W2364425913 title "The protection of ginsenoside Rb1 on RGC-5 damage induced by H_2O_2" @default.
- W2364425913 hasPublicationYear "2014" @default.
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