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- W2364432856 abstract "Objective:To investigate the therapeutic effects of recombinant human insulin-like growth factor(rhIGF)-1 on stress hyperglycemia in db/db type 2 diabetic mice.Methods:The stress hyperglycemia was induced in db/db mice by means of electric pulse stimulation.Thereafter,the mice were subjected to the treatment of insulin or rhIGF-1 separately.The level of blood glucose was measured .The expression of glucose transporter type 4(GLUT4) gene in the skeletal muscle was determined by real-time PCR,and the amount of GLUT4 molecules was detected by western blot.Results:Compared with normal control,obesity,hyperglycemia and hyperinsulinemia were found in db/db mice at the age of 8 weeks.After electric pulse stimulation there was a significant difference in the level of blood glucose between db/db mice and control groups(F = 48.915,P 0.05).However,there was no significant difference in the level of blood glucose in different time points of intra-group(F = 1.295,P 0.05),and no interaction between groups and time points(F = 1.046,P 0.05).After treatments,significantly alternated glycemia can be seen between either different groups(F = 36.947,P 0.05) or different time points(F = 13.880,P 0.05).And there was interaction between the variations of group and time point a group-by-time interaction(F = 11.769,P 0.05).The expression of GLUT4 gene and GLUT4 cell membrane concentration in skeletal muscle cells were significantly increased by IGF-1 in diabetes db/db mice.Conclusion:rhIGF-1 has potential therapeutic effect on stress hyperglycemiae,which may be mediated by up-regulating GLUT4 expression and promoting GLUT4 membrane translocation in skeletal muscle cells of diabetes db/db mice." @default.
- W2364432856 created "2016-06-24" @default.
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- W2364432856 date "2011-01-01" @default.
- W2364432856 modified "2023-09-26" @default.
- W2364432856 title "Protective Effect of Recombinant Human IGF-1 on Stress Hyperglycemia in db/db Type 2 Diabetic Mice" @default.
- W2364432856 hasPublicationYear "2011" @default.
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