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- W2364439124 abstract "【Objective】To research the in vitro proliferation and Th1 type cytokine secretion effect of human peripheral blood mononuclear cells(PBMC) activated by Ag85B/IL-2 fusion protein.【Methods】After activated by different concentrations of Ag85B/IL-2 fusion protein at different hours,the proliferation activity of PBMC was analyzed by assay of MTT,and the Th1 type cytokine IL-12 and IFN-γ secreted by PBMC were detected with enzyme-linked immunoabsordent assay(ELISA) and compared with those of stimulated by Ag85B and BCG.【Results】The PBMC proliferation of 0.8μg/mL fusion protein stimulating group was highest and significantly higher than that of blank control group at different stimulating time(P0.01,P0.05).The IL-12 level was significantly higher than that of blank control groups when stimulated for at least 48 h at different stimulating concentrations(P0.01,P0.05),and the IL-12 secreting peak was at 0.8 μg/mL concentration for 72 h.The IFN-γ levels of 0.8 μg/mL and 1.6 μg/mL stimulating groups were significantly higher than those of control groups at different time(P0.01,P0.05),and the levels of IL-12 and IFN-γ of Ag85B/IL-2 fusion protein stimulating group were significantly higher than those of Ag85B and BCG stimulating groups(P0.01).【Conclusion】Ag85B/IL-2 fusion protein may promote the proliferation of human PBMC and Th1 type cytokine IL-12 and IFN-γ secretion." @default.
- W2364439124 created "2016-06-24" @default.
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- W2364439124 date "2006-01-01" @default.
- W2364439124 modified "2023-09-25" @default.
- W2364439124 title "Study on the in vitro Proliferation and Th1 Type Cytokine Secretion Effect of Human Peripheral Blood Mononuclear Cells Activated by Ag85B/IL-2 Fusion Protein" @default.
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