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- W2364440139 abstract "Objective:To investigate the changes of peripheral cardiotrophin-1(CT-1) and brain natriuretic peptide(BNP) concentrations in patients undergoing off-pump coronary artery bypass grafting(OPCABG), and the clinical significance of peripheral CT-1 and BNP in cardiac surgery thereof.Methods:Fifty elective OPCABG patients were included in the study.The concentrations of CT-1 and BNP were measured before surgery, and at 6 hours, 72 hours, 1 week and 10 months after the operation respectively.The clinical data of the heart function were also collected in patients .Results:(1)The peripheral CT-1 levels were significantly higher at 10 months after OPCABG than those before operation.(2)The concentration of peripheral BNP increased at 6 hours after operation.The peak level was found at 72 hours, and remained higher level until the 1 week after operation.The BNP concentration was returned to the normal level at 10 months after OPCABG.(3)The baseline levels of CT-1 and BNP were both positively correlated with NYHA rank and the diameter of the left ventricular end-diastolic dimension(LVEED), but negatively correlated with left ventricular ejection fraction(LVEF).However, no correlations were found between CT-1 and BNP and NYHA rank, LVEF or LVEED at 10 months after OPCAB.Conclusion:The perioperative blood BNP levels were increased significantly by OPCABG, while perioperative level of CT-1 increased slowly compared with that of BNP.In cardiac surgery,perioperative concentrations of CT-1 and BNP may reflect the cardiac function in patients before OPCABG.The further studies are warranted to assess the prognosis." @default.
- W2364440139 created "2016-06-24" @default.
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- W2364440139 date "2009-01-01" @default.
- W2364440139 modified "2023-09-26" @default.
- W2364440139 title "Changes of Cardiotrophin-1 and Brain Natriuretic Peptide after Off-Pump Coronary Artery Bypass" @default.
- W2364440139 hasPublicationYear "2009" @default.
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