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- W2364441445 abstract "Objective To investigate the clinical features and mutation patterns of HBV polymerase gene in patients with chronic hepatitis B(CHB) after the emergence of drug-resistance during Nucleos(t)ide analogues(NA) therapy.Methods The direct sequencing of PCR product was conducted to study HBV P gene RT region.70 CHB patients with virus breakthrough/rebound in nucleos(t)ide analogues treatment were selected from outpatients and hospitalized patients of CHB with NA(s)-resistant in the Beijing Youan hospital from Oct.2008 to May 2011.The clinical features after the emergence of NA(s)-resistant mutations were retrospectively analyzed.Results The median time duration of NA(s) treatment was 21(12-65) months.The median level of serum HBV DNA was(5.26±1.57) logcopies/ml.40(40/70) patients had HBV-reverse transcriptase resistance mutations.30(30/40)patients had mono-drug-resistance.10(10/40)patients had multiple drug resistant(MDR).31 patients had biochemical breakthrough.The patients with MDR all had multi-NA(s) administration experience,and had significant difference as compared with patients with single-drug resistant(P0.05).HBV DNA levels of in patients with biochemical rebound was higher than that in patients without biochemical rebound(P0.05).HBV DNA levels in patients with resistance mutations was higher than those without(P0.05).The difference in levels of HBV DNA levels and ALT were not significant between the single-drug resistant and the multidrug-resistant patients(P0.05).Conclusion The sequential therapy with nucleos(t)ide analogues(NAs) can screen out the multidrug-resistant virus.The biochemistry index and HBV DNA level are not significantly different between the single-drug resistant and the multidrug-resistant patients." @default.
- W2364441445 created "2016-06-24" @default.
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- W2364441445 date "2012-01-01" @default.
- W2364441445 modified "2023-09-26" @default.
- W2364441445 title "Clinical Characteristics of Virus Breakthrough/Rebound in Nucleos(t)ide Analogues Treatment in Patients with Chronic Hepatitis B" @default.
- W2364441445 hasPublicationYear "2012" @default.
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