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- W2364442249 abstract "Objective:To investigate the effect of 1,25(OH)2D3 on gene expression profiles in Th cells of rat spleen.Methods:Lewis rats had been fed with 1,25(OH)2D3(1μg per rat a day) for 14 days.The control group were administered the isotonic Na chloride as the same volume as the experimental group,and then LPS(10 mg/kg) was administered intraperitoneally in both groups at the 15th day,the animals were sacrificed 6 hours later.Gene expression in Th cells of rat spleen was analyzed by cDNA microarray technology.Results of gene array were verified by Real-time-PCR.Results:A total of 35 genes exhibited differential expression in Th cells of rat spleen compared with control.12 genes were up-regulated and 23 genes were down regulated,which include Th cytokines and transcription regulators genes.Conclusions:1,25(OH)2D3 has a great influence on the gene expression in Th cells of rat spleen.1,25(OH)2D3 inhibits Th1 inflammation,bias the immune response towards Th2 pathway.1,25(OH)2D3 modulates Th cells differentiation regulating gene expression profiles of Th cytokines and transcription regulators." @default.
- W2364442249 created "2016-06-24" @default.
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- W2364442249 date "2007-01-01" @default.
- W2364442249 modified "2023-09-24" @default.
- W2364442249 title "The effect of 1,25(OH)_2D_3 on gene expression profiles in Th cells of rat spleen" @default.
- W2364442249 hasPublicationYear "2007" @default.
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