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- W2364446003 abstract "Objective Observed in vitro and in vivo experiments the new formulation of K-ConB-JN compound the protective effect of the the CVB3 virus infection of myocardial cells and mice with viral myocarditis. Methods(1) In vitro experiments: After Myocardial cells infection with 1000 TCID50 of CVB3,different concentrations the new formulation of K-ConB-JN compound and ribavirin were investigated in vitro,and set the normal group and model control group.The cytopathic reach 75%,determination of cell supernatant fluid of CK,AST and LDH activity.(2)In vivo experiments: Balb/c mice infected with CVB3 caused by viral myocarditis model,and given the new formulation of K-ConB-JN compound high 、medium 、low-dose,ribavirin and pure water intragastrically 14 days.Record the number of mice died,observe the drug to mice death protection situation. ResultsThe new formulation of K-ConB-JN compound could reduce CVB3 infection myocardial cell medium CK,AST and LDH content,and reduce the mortality of infection in mice,Administered group and model control group compared P0.05. ConclusionThe new formulation of K-ConB-JN compounds have a protective effect on CVB3-infected myocardial cells and mouse." @default.
- W2364446003 created "2016-06-24" @default.
- W2364446003 creator A5030642508 @default.
- W2364446003 date "2013-01-01" @default.
- W2364446003 modified "2023-09-25" @default.
- W2364446003 title "Coxsackie B viral myocarditis capsule compound extract on CVB3" @default.
- W2364446003 hasPublicationYear "2013" @default.
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