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- W2364446852 abstract "INTRODUCTION: Ovarian steroid cell tumors, not otherwise specified (NOS), represent 0.1% of all ovarian neoplasm. To our knowledge, cumulative data on steroid cell tumors has not been published. We present a series of four consecutive cases. METHODS: Patients treated for ovarian steroid cell tumor NOS, at three tertiary institutions between 2008 and 2015 were identified by retrospective chart review. Clinical features, tumor characteristics, treatment and outcome were studied. RESULTS: Two patients (age 64, 86) had small 1.8–2.1 cm non-invasive tumors limited to the ovary and two patients (age 48, 57) had large tumors with possible capsular invasion (12 cm) and peritoneal metastasis (15 cm). All four patients had evidence of hirsutism and/or virilization. Three patients had significantly elevated serum testosterone (96–839 ng/dL). No patient exhibited hyperesterogenism. The metastatic tumor had large tumor necrosis, Grade 2–3 nuclear atypia, and strongly positive staining for Immunoperoxidae, Inhibin, and Vimentin. Only the patient with metastatic disease received adjuvant chemotherapy after initial surgery. She is alive after 62 months with recurrent progressive disease. Three patients who did not receive adjuvant treatment remain disease-free after an average follow-up of 35 months. CONCLUSION: Natural history and management of ovarian steroid cell tumor NOS remain unclear. In our small case series, younger age at diagnosis and larger tumor size, but not relative increase in virilization or testosterone level, were observed in possibly invasive and metastatic disease compared to disease compared to non-invasive disease. Collaborative development of a larger case series will increase our understanding of this rare tumor and help establish a management consensus." @default.
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- W2364446852 date "2016-05-01" @default.
- W2364446852 modified "2023-09-25" @default.
- W2364446852 title "Hair in all the Wrong Places" @default.
- W2364446852 doi "https://doi.org/10.1097/01.aog.0000483554.26735.ca" @default.
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