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- W2364450304 abstract "ObjectiveTo establish a model of T cells anergy induced by superantigen in vitro. MethodsPBMCs were stimulated by SEA for 72 hours and then maintained with exogenous rIL-2 for two weeks to obtain resting transient SEA-reactive T cells line;Through Ficoll-Hypaque centrifugation, anergic T lymphoblasts stimulated repeatedly by SEA were obtained. ResultsIt was shown that resting transient SEA-reactive T cells line could be obtained through SEA and rIL-2 stimulation;T cells stimulated by SEA became unresponsive repeatedly. Contrast to SEA activated T cells, DNA synthesis and IL-2 production in anergic T cells appeared to be significantly reduced,but its proliferation could be restored after resting for a short time. ConclusionT lymphocytes stimulated by SEA repeatedly become anergic in vitro." @default.
- W2364450304 created "2016-06-24" @default.
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- W2364450304 date "2001-01-01" @default.
- W2364450304 modified "2023-09-23" @default.
- W2364450304 title "Model of T cells anergy induced by superantigen SEA in v itro" @default.
- W2364450304 hasPublicationYear "2001" @default.
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