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- W2364451876 abstract "To study the mechanism of pancreatic β cell dysfunction and tissue resistance to insulin, and to provide basis for early diagnosis and therapy of the disease, the levels of APN, insulin, sensitive C-reactive protein and leptin in the serum of patients with type 2 diabetes mellitus were determined. Altogether 184 untreatea type 2 diabetes mellitus patients, 30 normal people as the control group, and another 75 type 2 diabetes mellitus patients who have been treated for a year were enrolled in this study. The serum levels of the above indexes were determined by chemiluminescence immunoassay, enzyme immunoassay and radioimmunoassay. The results showed that there were obvious differences in the levels of insulin, leptin, C-reacting protein and insulin antibody between the normal control group and the group of the untreated type 2 diabetes mellitus patients (P0.01), especially there was significant difference in the level of APN(P(0.001)). Among the 75 type 2 diabetes mellitus patients who have received a year's treatment, all the indexes except for APN and insulin antibody were decreased statistically, while the APN level was increased significantly (P0.01) than that before the treatment. The determination of markers of type 2 diabetes mellitus is of great significance for its early diagnosis, therapy, prognosis and mechanism research." @default.
- W2364451876 created "2016-06-24" @default.
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- W2364451876 date "2005-01-01" @default.
- W2364451876 modified "2023-09-24" @default.
- W2364451876 title "Analysis of the Variation Levels of APN, Insulin, Sensitive C-Reactive Protein and Leptin in the Serum of Patients with Type 2 Diabetes Mellitus" @default.
- W2364451876 hasPublicationYear "2005" @default.
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