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- W2364454776 abstract "Objective To investigate the protective effect of zinc and vitamin A on testis injury of rats induced by chronic alcohol intake and its possible mechanism.Methods 40 healthy Sprague-Dawley adult male rats were randomly divided into 4 groups:control group,alcohol group(7.5g/kg),alcohol+zinc group(alcohol 7.5g/kg+zinc gluconate 7.7mg/kg),and alcohol+vitamin A group(alcohol 7.5g/kg+vitamin A 50μg/kg).The alcohol,zinc gluconate and vitamin A were administrated to the rats for 13 weeks by a gastric tube.The sperm counting,motility and the percentage of abnormal sperm were observed.The serum sexual hormones(T,LH,FSH)were determined.The pathological changes of testicle tissue of rats were observed by light and electron microscopy.The malonaldehyde(MDA)contents in testicular mitochondria were simultaneously determined.The expression of iNOS in testes was detected by immunohistochemistry.Results As compared with control group,the sperm counting and motility in alcohol group were significantly decreased(P0.05).The frequency of abnormal sperm was obviously increased(P0.05).The serum levels of T,LH,FSH were significantly decreased(P0.05).The MDA content and the expression of iNOS were markedly higher than those of control group(P0.05).Histological evaluation for testes revealed that seminiferous epithelium was disorganized and the sertoli cells and germ cells were degenerated in alcohol-treated rats.Zinc or vitamin A supplementation decreased the testicular mitochondrial MDA formation and the expression of iNOS in testes,as a result,the germ cells degeneration was improved,sperm counting and motility were higher than those in alcohol group,however,which couldn't prevent the decrease of serum levels of sexual hormones(T,LH,FSH)(P0.05).Conclusion Zinc or vitamin A supplementation limites the testicular peroxidation injury,which is a result of chronic alcohol exposure.To a certain degree zinc or vitamin A supplementation can protect the spermatogenesis function." @default.
- W2364454776 created "2016-06-24" @default.
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- W2364454776 date "2010-01-01" @default.
- W2364454776 modified "2023-09-24" @default.
- W2364454776 title "Protective effect of zinc and vitamin A on testis injury of rats induced by chronic alcohol intake" @default.
- W2364454776 hasPublicationYear "2010" @default.
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